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Author

Wen-Hua Xu

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Aug 2026

Zwitterionic Brush-Engineered Molecular Spherical Nucleic Acids for Enhanced Intracellular Antisense Activity.

Spherical nucleic acids (SNAs) enhance antisense oligonucleotide (ASO) uptake and nuclease resistance, but their activity is often constrained by inefficient intracellular trafficking. Here, we developed a zwitterionic brush-engineered molecular SNA (EmSNA) to improve ASO delivery. EmSNA was constructed by grafting pol...

Rui Xu, Xiu-Ying Sun, Li Yan et al. · 0 citations

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