The asymmetric synthesis of 1,4-dicarbonyl compounds bearing all-carbon quaternary stereocenters remains a significant challenge in organic synthesis. Herein, we report a photoredox/nickel dual-catalyzed tandem radical addition and oxidation protocol that directly converts β-keto esters and styrenes into enantioenriche...
Chiral medium-sized rings, defined herein as 7- to 11-membered cyclic frameworks, are common in bioactive molecules and occupy an important but still underexplored region of drug-like chemical space. Their asymmetric synthesis remains formidably challenging, as conformational flexibility, transannular interactions, and...
Yu-Jie Li, Xue-Rui Wang, Qiang Wang et al.· Chemical Reviews· 0 citations
Sulfinamides and related sulfur(VI) motifs are widely represented in bioactive molecules; however, their direct installation onto alkenes has traditionally relied on Lewis acid- or transition metal-mediated two-electron pathways, with more recent advances dominated by photoinduced single-electron processes. Here, we re...
