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Wen-Long Zhou

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Review Open access Sep 2026

Long-acting RNAi therapeutics in hypertension: limitations of single-target AGT silencing and rational multi-target synergistic strategies

Hypertension affects over 1.3 billion people worldwide, fewer than 20% achieve adequate blood pressure (BP) control. Poor long-term BP management accelerates irreversible damage to target organs, highlighting the urgent need for novel therapeutic approaches. Small interfering RNAs (siRNAs) are synthetic oligonucleotide...

Yi-Tong Lan, Xiao-Xia Ye, Qing-Wei Zeng et al. · 0 citations

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