Author

Wenqian Dong

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Open access Aug 2026

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Extracellular targeted protein degradation (eTPD) systems typically utilize lysosome-targeting receptors (LTRs) to mediate internalization and lysosomal degradation of extracellular and membrane proteins. While multiple LTRs have been discovered, there remains a compelling need to seek for new LTRs, particularly those...

Lu Chen, Xin-Ying Fu, Wen-Qian Dong et al. · bioRxiv · 0 citations

Sep 2026

MoTRANet: Safety-Aware Drug Recommendation via Molecular Representation Learning and Dynamic Patient Modeling.

Experimental results demonstrate that MoTRANet outperforms existing mainstream baseline methods in terms of Jaccard, F1, and PRAUC, while achieving a relatively low DDI rate, validating the model's accuracy and safety.

Peng-Tao Jia, Jun-Hao Gao, Jing-Tao Sha et al. · IEEE transactions on computa... · 0 citations

Open access Aug 2026

TROP2-targeting chimeras (TRTACs) for tumor-selective membrane protein degradation and enhanced drug delivery

These findings establish TROP2 as a robust LTR and provide a versatile eTPD platform with profound translational potential for tumor treatment, as well as design TRTAC-drug conjugates, enabling targeted protein degradation together with enhanced drug delivery.

Lu-Ping Chen, Xinying Fu, Wenqian Dong et al. · bioRxiv · 0 citations