Integrated analysis of autophagy and ferroptosis mediating aristolochic acid A-induced nephrotoxicity via transcriptome and m6A epigenetic transcriptome in HK-2 cells
Introduction Aristolochic acid A possesses anti-inflammatory, antispasmodic and diuretic pharmacological activities, while exerting strong toxic effects that cause irreversible renal tubular injury, renal fibrosis and malignant tumors such as urothelial carcinoma. This study aimed to elucidate the relationship between...