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Wen-Qing Jia

2 papers indexed here

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Open access Oct 2026

In Silico Evaluation via Virtual Screening, ADMET Profiling and Molecular Dynamics Simulations: Synthesis and Biological Activity Analysis of a Novel Antitumor PI3K Inhibitor

The PI3K plays a crucial role in cancer progression, and the development of PI3K inhibitors has always been a hot research direction in oncology. Through virtual screening and docking, potential lead compounds were identified. ADMET prediction revealed that KTC101 possesses superior pharmacokinetic profile. Molecular d...

Wen-Qing Jia, Yu-Kui Ma, Zhe Zhang · 0 citations
Open access Sep 2026

Targeting PI3Kα with Small Molecules: Progress and Challenges in Tumor Treatment

Aberrant activation of PI3Kα tightly correlates with tumorigenesis and advancement. PI3Kα inhibitors can bring significant clinical gains to patients with PIK3CA-mutant breast cancer and other solid tumor patients by inhibiting tumor cell growth and regulating the immune microenvironment. Alpelisib, a selective PI3Kα i...

Wen-Qing Jia · 0 citations

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