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Wen-Shu Wu

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Open access Jul 2026

Dual-modal antioxidant and epigenetic synergy attenuates the self-perpetuating senescence cycle in osteoarthritis

Cartilage-targeted HPcLW nanoparticles are fabricated via electrostatic self-assembly of human serum albumin and poly-L-lysine with collagen II-binding peptide, co-loaded with lycopene and WTAP siRNA to counteracts the senescence loop, establishing the WTAP/PAI-1 axis as a therapeutic target and highlighting co-deliver...

Xue-Ying An, Han-Tao Cai, Wen-Shu Wu et al. · 0 citations

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