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Open access Sep 2026

SMORE: joint dimension reduction and cell population discovery on single-cell methylome data

Single-cell DNA methylation profiling technology captures novel epigenetic data modality but are challenging to analyze because of their heterogeneity, high dimensionality, and ultra-sparsity. Here we present SMORE (Single-cell MethylOme Reduction and Embedding), a computational method for joint dimensionality reductio...

Jing-Wen Deng, Zi-Xi Wang, Wen Tang et al. · 0 citations

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