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Wen-Tao Dong

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Open access Oct 2026

Lysosomal lipidomics identifies glycosylated bis(monoacylglycero)phosphate as a novel biomarker of mutant GBA1

Mutations in GBA1, which encodes the lysosomal enzyme glucocerebrosidase (GCase), cause Gaucher disease (GD) and represent a major genetic risk factor for Parkinson’s disease (PD). PD clinical trials targeting or monitoring GCase canonical substrates (Glucosyl-ceramides/sphingosine) have failed to achieve their targets...

Cindy Lin, Miharu Iguchi, Jacob Oh et al. · 0 citations

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