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Author

Wen-Xi Zhang

2 papers indexed here

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Open access Sep 2026

Regulation of immune signal integration and memory by inflammation-induced chromosome conformation

Significance Innate immune cells integrate inflammatory cues and retain transcriptional memory, a phenomenon previously attributed mainly to one-dimensional epigenetic mechanisms. We show that inflammatory cytokine exposure remodels the three-dimensional (3D) genome of macrophages by establishing stable chromatin loops...

Bence Daniel, Andy Y. Chen, Katalin D. Sandor et al. · 1 citation
Jul 2026

Cell cycle-coupled transcriptional network regulates human B cell fate bifurcation 2257411

A generalizable framework for assembling and testing GRNs in the context of immune cell fate decisions is established, and previously unreported feedback loops that link cell division to fate specification are revealed.

Nicholas A. Pease, Jing-Yu Fan, S. Keshari et al. · 0 citations

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