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Open access Aug 2026

A compact five-gene immuno-fibrotic profile distinguishing systemic sclerosis subtypes with PXDN validated as a fibrosis-associated target

The integrative analysis identifies a concise immunofibrotic gene signature that robustly distinguishes SSc and its major subtypes, highlighting a potential nexus of immune-stromal interactions that may underlie disease heterogeneity, offering candidate biomarkers for molecular stratification and therapeutic targeting.

Xiang-Yue Zhao, Ke-Jian Hu, Yin-Zhi Cui et al. · 0 citations
Review Open access Aug 2026

α2-3-sialylated glycosphingolipids in neuroinflammation, immunity, and programmed cell death: mechanistic evidence and context-dependent regulation: a comprehensive review

A lipid–inflammation–immunity–cell death framework that organizes potentially shared downstream processes while explicitly retaining disease-specific differences is proposed that organizes potentially shared downstream processes while explicitly retaining disease-specific differences.

Xiao-Cheng Li, Lu Li, Xin-Meng Liu et al. · 0 citations

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