Open access
Oct 2026
H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease
ABSTRACT Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra, with mitochondrial dysfunction central to its pathology. Recent studies have linked lactate—accumulating in PD due to mitochondrial dysfunction—to disease mechani...
Ying-Yao Liu, Xi Li, Wen-Xuan He et al.
· Advancement of science · 0 citations