Author

Wen-Xue Li

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Sep 2026

Abstract B059: Loss of Cullin-RING Ligase 5 mediates resistance to RAS inhibition in pancreatic cancer

The proto-oncogene KRAS is mutated in greater than 90% of pancreatic ductal adenocarcinoma (PDAC). Although newly developed multi-RAS(ON) inhibitors (daraxonrasib) have significantly improved progression-free and overall survival compared with current standard-of-care chemotherapy in PDAC patients, both clinical and...

Cassandra S. Markham, Ilze M. Olivi Gomes, Yi Di et al. · Cancer Research · 0 citations

Open access Jul 2026

METTL3 promotes cell-cycle progression via activation of transcriptional elongation.

Transcriptional elongation undergoes extensive remodeling at mitotic entry, yet how elongation control is integrated into core cell-cycle kinase networks remains unclear. Here, we identify the m6A methyltransferase METTL3 as a direct substrate of the mitotic kinase CDK1 in mammalian cells. CDK1-dependent phosphorylatio...

Azime Akçaöz-Alasar, Yanhua Wang, Hang Li et al. · Molecules and Cells · 1 citation