Wen-Yao Zhong

Clinical and genetic features, surgical management, and longitudinal follow-up in two children with progressive osseous heteroplasia

Progressive osseous heteroplasia (POH) is an ultrarare disorder characterized by heterotopic ossification that progresses from the skin and subcutaneous tissues into deeper connective tissues. Most affected individuals harbor heterozygous inactivating variants in GNAS , whereas postzygotic mosaic variants have...