Author

Wen-Yue Liu

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Open access Oct 2026

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

ABSTRACT Acquired resistance to gemcitabine (GEM) remains a major barrier to effective treatment of pancreatic ductal adenocarcinoma (PDAC). Here we identify histone H3K18 lactylation (H3K18la), induced by GEM‐driven lactate accumulation, as a key epigenetic mechanism of chemoresistance. H3K18la functions as a transcri...

Li-Jun Zhao, Jian-Zhong Cao, Wen-Yue Liu et al. · Advancement of science · 0 citations

Review Aug 2026

The niche-metabolism axis: reprogramming tumor-associated macrophages for precision immunotherapy.

This framework highlights that therapeutic paradigms should shift from nonselective TAM depletion to niche-specific metabolic-epigenetic reconstruction, providing a precise roadmap for designing next-generation engineered macrophage therapies.

Li-Jun Zhao, Xu-Yun Li, Wen-Yue Liu et al. · Trends in Molecular Medicine · 0 citations