Open access
Sep 2026
Nucleome dynamics and histone priming by pioneer transcription factors drive osteoblast differentiation.
Functional maturation of osteoblasts from skeletal stem cells requires genome-wide transcriptional reprogramming, coincident with remodeling of transcribed (A) and inactive (B) chromatin compartments. Here, we assessed whether pioneer factor-driven histone activation links compartment remodeling to osteogenic transcrip...
JaeWoo Moon, Seung Gwa Park, H. Yoon et al.
· Cell Reports · 0 citations