Author

Wen Zhang

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Review Open access Aug 2026

Metabolic–epigenetic crosstalk in latent autoimmune diabetes in adults: potential roles of lactate-induced histone lactylation in immune regulation and pancreatic β-cell fate

Latent autoimmune diabetes in adults (LADA) is clinically between type 2 and type 1 diabetes with progressive autoimmune loss of β-cells and variable insulin dependence. Lactate was once thought to be a glucan byproduct and is now recognized as a signaling enzyme regulating gene expression via lysine lactylation. One o...

Wen Zhang, Xiao-Ran Wang, Bing He et al. · Frontiers in Endocrinology · 0 citations

Review Aug 2026

Engineered Mesenchymal Stem Cell‐Derived Extracellular Vesicles as Antifibrotic Nanotherapeutics for Chronic Kidney Disease

Chronic kidney disease (CKD) affects more than 850 million people worldwide, and progressive renal fibrosis is the most common cause of irreversible renal loss. Mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) are nanoscale membrane‐bound particles carrying bioactive proteins, lipids, and regulatory RNAs...

Wen Zhang, Su-Mei Xu, Zhi-Jian Cao et al. · Advanced Healthcare Material... · 0 citations

Review Sep 2026

The Ferroptosis-Immunity Axis in Diabetic Kidney Disease: Emerging Therapeutic Targets.

SIGNIFICANCE Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease worldwide. Its burden continues to increase despite advances in glycemic and blood pressure control. This persistent risk highlights the need for therapeutic strategies that address injury-amplifying mechanisms beyond conventional...

Wen Zhang, Su-Mei Xu, Zhi-Jian Cao et al. · Antioxidants and Redox Signa... · 0 citations