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Author

Wen Zhao

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2 papers indexed here

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Open access Sep 2026

High TG/low HDL-C ratio–mimetic lipid stress drives diabetic atherosclerotic endothelial–macrophage dysfunction through glycocalyx disruption and CD36/ABCA1 imbalance

A high triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is strongly associated with insulin resistance and atherosclerotic cardiovascular risk, but the cellular mechanisms linking this lipid imbalance to vascular injury remain incompletely defined. This study established a combined hyperglycemic/high...

Le-Chang Bi, Wen Zhao, Ming-Jing Lu et al. · 0 citations
Sep 2026

Liensinine Promotes Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via p38 MAPK-Mediated Mitochondrial Pathway: An In Vitro Multi-Omics and Functional Validation Study.

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation and joint destruction. Oxidative stress has been implicated in its pathogenesis. This in vitro study aimed to investigate the effects of liensinine (LIE) on the apoptosis of fibroblast-like synoviocytes (FLSs) and its und...

Shou-Di He, Mian Peng, Jun-Tong Wei et al. · 0 citations

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