Author

Wenhai Yu

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Open access Aug 2026

Targeting host lipogenesis with a diarylamide inhibitor disrupts SARS-CoV-2 replication

Summary The vulnerability of direct-acting antivirals to resistance has motivated interest in host-directed strategies that target conserved cellular pathways essential for viral replication. Here, we report a diarylamide molecule, compound 10 (compd. 10), which inhibits SARS-CoV-2 more potently than the parent clofoct...

Xintian Zhang, Tingfu Du, Yong-Jian Wang et al. · iScience · 0 citations

Open access Jul 2026

Dynamic m6A epitranscriptomic remodeling coordinates host transcriptional reprogramming during MPXV infection.

BACKGROUND The global emergence of monkeypox virus (MPXV) highlights the urgent need for a deeper understanding of host-pathogen interactions. Although transcriptional responses to MPXV infection have been characterized, the role of epitranscriptomic regulation particularly N6‑methyladenosine (m6A) modification remains...

R. Tang, Jin-Di Huang, Wenhai Yu et al. · Cell communication and signa... · 0 citations