Wenhua Liang

Integrative cfDNA profiling from low-pass whole-genome sequencing enables tissue-of-origin prediction in cancer

Cancer type classification is challenging due to tumor heterogeneity and undefined tissue of origin (TOO), particularly in cancers of unknown primary (CUP) and multiple primary cancers (MPC). Accurate TOO identification is critical for guiding treatment and prognosis. We developed a stacked ensemble machine learning cl...