Author

Wenhui Zhao

2 papers indexed here

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Review Open access Aug 2026

Cyclin-dependent kinase 4 and 6 inhibitors and the breast cancer immune ecosystem: immune remodeling, resistance, and therapeutic reprogramming

Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6 inhibitors) combined with endocrine therapy have become a therapeutic backbone for hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer, yet durable disease control is frequently limited by intrinsic and acquired resistance. Canoni...

Yu-Han Tang, Ying-Ze Zhu, Shao-Chun Liu et al. · Frontiers in Immunology · 0 citations

Review Open access Jul 2026

ADAM12 in a stromal-checkpoint framework: integrating tumor microenvironment remodeling and therapy resistance in solid tumors

An integrative stromal-checkpoint framework is used to describe stromal programs that couple extracellular matrix remodeling, metabolic stress, vascular dysfunction, and immune exclusion into treatment-resistant tumor ecologies and discusses how ADAM12-informed biomarkers, spatial barrier profiling, and stromal-priming...

Shao-Chun Liu, Jian Xu, Han Zhang et al. · Cell Communication and Signa... · 1 citation