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Author

Wenjing Jin

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3 papers indexed here

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Review Open access Oct 2026

Context-dependent cGAS–STING signaling in inflammatory bowel disease: cell specificity, lesion state, and therapeutic windows

Whether cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling should be inhibited in inflammatory bowel disease (IBD) cannot be answered from pathway abundance alone. Canonical ER–Golgi–TBK1–IRF3/NF-κB signaling can amplify intestinal inflammation, whereas nuclear STING–AHR signaling, T-cell-i...

Hui-Xi Bian, Wen-Jing Jin, Yu-Hong Chen et al. · 0 citations
Oct 2026

Discovery of C5-Substituted 2′-Fluorinated Pyrimidine Nucleosides as Potent and Orally Efficacious Anti-HSV Agents

Herpes simplex virus (HSV) infections remain a significant global health concern. Through phenotypic screening of a nucleoside-focused library followed by systematic structure−activity relationship (SAR) explorations, we identified C5-substituted 2′-fluorinated pyrimidine nucleosides as promising anti-HSV scaffolds....

Ye Li, Wen-Bo Zhang, Shu-Wen Xue et al. · 0 citations
Aug 2026

Discovery of pyridine formyl hydrazide derivatives as potent non-nucleoside RSV polymerase inhibitors.

Respiratory syncytial virus (RSV) is an RNA virus that infects both the upper and lower respiratory tract and is recognized as a major respiratory health threat. In this study, guided by the cryo-EM structure of the MRK-1-RSV polymerase complex, the substituent region at the C4 position of the shared pyridine core was...

Xin Li, Jinyuan Wu, Lin Zheng et al. · 0 citations

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