Berberine alleviates postoperative cognitive dysfunction by suppressing microglial IDO1 induction and kynurenine pathway activation in aged mice.
Postoperative cognitive dysfunction (POCD) is a common complication of surgery in elderly patients, and no pharmacological therapy has been approved. Although indoleamine 2,3-dioxygenase 1 (IDO1)-driven kynurenine pathway activation has been linked to perioperative neurocognitive impairment, neither the cellular source...