Open access
Jul 2026
Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.
It is shown that AD model mice expressing a mitophagy reporter (APP/PSEN1/mt-Keima) develop large accumulation of acidic and neutral mitochondria within neuronal processes that form a previously unrecognized pathological structure termed mitochondrial plaques (MPs).
Xiuli Dan, D. L. Croteau, Wenlong Liu et al.
· Nature Neuroscience · 1 citation