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Wenlong Liu

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Open access Jul 2026

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.

It is shown that AD model mice expressing a mitophagy reporter (APP/PSEN1/mt-Keima) develop large accumulation of acidic and neutral mitochondria within neuronal processes that form a previously unrecognized pathological structure termed mitochondrial plaques (MPs).

Xiuli Dan, D. L. Croteau, Wenlong Liu et al. · 1 citation

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