Dibutyl phthalate disrupts ESR1-GPX4 redox signaling and aggravates ovarian dysfunction in a PCOS-like mouse model.
Dibutyl phthalate (DBP), a widely used phthalate plasticizer, has been implicated in reproductive toxicity, but the molecular mechanisms by which experimental DBP exposure affects ovarian granulosa-cell function remain incompletely defined. In an exploratory clinical cohort, urinary MiBP, MnBP, and DBP levels were high...