Author

Wenqian Xu

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Open access Jul 2026

ETV6 Rearrangement Suppresses CDKN1B Transcription by Disrupting an Intragenic Super-Enhancer in Acute Lymphoblastic Leukemia.

It is demonstrated that ETV6 functions as a regulatory element via ETV6-SE in ALL, with CDKN1B as a key target and CRISPR interference and knockout experiments revealed the core enhancer region within ETV6-SE responsible for CDKN1B regulation.

Wenqian Xu, Xiaofang Ma, Xue Sun et al. · Cancer Research · 0 citations