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Author

Wenqiang Sun

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Open access Jul 2026

Integrated Multi-Omics Elucidates the Therapeutic Potential and Mechanisms of Andrographolide in Colorectal Cancer

It is demonstrated that AGL exerts potent anti-CRC activity primarily through the induction of G1-phase arrest and apoptosis, supporting its potential as a promising natural lead compound for the development of novel CRC therapeutics.

Haocheng Guan, Yongchao Li, Menglong Xu et al. · 0 citations
Aug 2026

Dual-restricted AAV gene delivery via suprachoroidal administration mediates precision RPE SOCS3 restoration for dry age-related macular degeneration.

A dual-restricted ocular gene delivery platform that combines suprachoroidal administration with an RPE-specific Best1 promoter enables localized, durable, and cell-restricted SOCS3 expression, supporting suprachoroidal AAV-Best1-SOCS3 delivery for localized modulation of oxidative-inflammatory retinal degeneration.

Yiquan Zhang, Fu-Xiao Luan, Jing Feng et al. · 0 citations

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