Aug 2026
Discovery of DCAF16-based PROTACs as SHP2 degraders.
The design and synthesis of SHP2 PROTACs that recruit the DCAF16 E3 ligase for targeted SHP2 degradation are reported that support the potential of SHP2-targeted protein degradation as an alternative strategy to enzymatic inhibition and provide a promising starting point for the further development of SHP2 degraders.
X. Pang, Yuxin Gan, Qingyuan Hu et al.
· Bioorganic chemistry (Print) · 0 citations