Jul 2026
Mir452 protects against septic acute kidney injury by targeting Apaf1 to relieve CASP9-mediated suppression of autophagy.
It is reported that Mir452 protects kidney tubular cells in septic AKI by repressing APAF1 and associated caspase activation and thereby inhibiting apoptosome-mediated CASP9 activation to preserve macroautophagy/autophagy.
Zhiwen Liu, Ying Fu, Wenwen Wu et al.
· Autophagy · 1 citation