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Wenxiang Xue

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Open access Jul 2026

Coronavirus papain-like protease antagonizes innate immunity by cleaving Importin α1 to disrupt nuclear transport

The PLpro-TM protein is identified as a pan-coronavirus antagonist of nucleocytoplasmic trafficking and innate immune response and established PLpro-TM-mediated cleavage of Importin α1 as a conserved immune evasion strategy across coronaviruses and highlights this interaction as a potential target for broad-spectrum an...

Jie-Huang Wang, Wenxiang Xue, Ying-Jie Sun et al. · 0 citations

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