Histopathology-guided multimodal pathomics identifies a PLEKHA6-positive epithelial state associated with phosphoinositide metabolism in esophageal cancer.
Esophageal cancer is biologically heterogeneous, and conventional clinicopathological staging incompletely captures variation in patient outcomes. This study aimed to determine whether histopathology-derived features associated with phosphoinositide metabolism could support exploratory prognostic stratification and ide...