FOXO3 Counteracts Oxidative Stress-Induced Nucleus Pulposus Cell Senescence via BNIP3-Mediated Mitophagy in Intervertebral Disc Degeneration.
Oxidative stress and mitochondrial reactive oxygen species (ROS) accumulation are central drivers of nucleus pulposus (NP) cell senescence and intervertebral disc degeneration (IVDD), yet the transcriptional programs that maintain mitochondrial redox homeostasis in NP cells remain poorly defined. In this study, we inve...