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Willem F. Weber

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Open access Sep 2026

Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins

Beta-arrestins (β-arrs) are cytosolic proteins which mediate G protein-coupled receptor (GPCR) desensitization, endocytosis, and signaling. Despite the widespread physiological roles of β-arr coupling, the molecular basis of GPCR/β-arr interaction has been studied primarily in monomeric family A GPCRs. Here we develop...

Dagan C. Marx, Alberto J. Gonzalez-Hernandez, Joon Lee et al. · 1 citation

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