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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Willi Temme

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2 papers indexed here

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Sep 2026

Ceapin‐A7 Suppresses UPR Signaling and Mitigates Retinal Neovascularization in Vldlr−/− Mice

Pathological neovascularization drives blinding retinal diseases, including diabetic retinopathy, retinopathy of prematurity, and neovascular age‐related macular degeneration. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling are key mechanisms underlying neovascularization. Mice lacking t...

Soyoung Park, Angela Galdamez, Willi Temme et al. · 0 citations
Open access Sep 2026

Chemical induction and reversal of photoreceptor dystrophy in retinal organoids.

Activating transcription factor 6 (ATF6) controls a signal transduction pathway of the unfolded protein response (UPR). Loss-of-function ATF6 mutations cause inherited photoreceptor diseases. Ceapin-A7 is a non-toxic, cell-permeable small molecule that selectively inhibits ATF6. We investigated how ATF6 inhibition impa...

Allyssa Bradley, Hyejung Min, Soyoung Park et al. · 0 citations

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