William A. McEwan

Templated paired helical filament formation and tau fold-dependent inclusion morphologies in primary neurons

Neurodegenerative tauopathies are characterized by the abnormal assembly of tau into amyloid filaments with distinct, disease-specific folds. These filaments are proposed to spread in a prion-like manner, thus underlying the progression of pathology in diseased brains. A prediction of this hypothesis is that tau filame...