Introduction Dectin-1, encoded by Clec7a, is highly expressed in disease-associated microglia in Alzheimer’s disease (AD), yet its in vivo function remains largely unknown. Methods We generated Clec7a-floxed mice and conditionally deleted dectin-1 in microglia to determine its effects on pathology and behavior using th...
Wen-Tin Xi, R. Rodriguiz, William C. Wetsel et al.· Frontiers in Immunology· 0 citations
Psychedelic drugs, such as lysergic acid diethylamide and psilocybin, have emerged as potentially transformative therapeutics for various neuropsychiatric conditions, including depression, anxiety, post-traumatic stress disorder, migraine and cluster headaches. Classical psychedelics exert their effects through activat...
Yi-Ting Chiu, A. Y. Deutch, Wei Wang et al.· Nature Neuroscience· 0 citations
Beneficial and maladaptive opioid effects are difficult to dissociate, partly because dopamine signaling contributes to both. Here we show that associative opioid-reward learning can be blocked even under conditions that elevate dopamine in the nucleus accumbens. We developed naloxoneDART, a cell-type-specific analogue...
S. Yousefzadeh, Haidun Yan, Seung‐Hwa Kwak et al.· Nature· 1 citation
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