Open access
Jul 2026
Receptor allostery promotes context-specific Sonic Hedgehog signaling during embryonic development
The authors identify a binding site on the Sonic Hedgehog signaling protein Smoothened for the allosteric regulator arachidonic acid (AA) and show that its disruption attenuates SHH- and sterol-stimulated SMO induction.
M. Dillard, Christina A. Daly, Rojalin Pradhan et al.
· Nature Communications · 0 citations