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Author

William D. Foulkes

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Jul 2026

Abstract IA003: DICER1-related tumor predisposition: genotypes, phenotypes and mechanisms

DICER1 is an endoribonuclease that plays a critical role in microRNA (miRNA) biogenesis. DICER1 contains two catalytic ribonuclease domains: RNase IIIa and RNase IIIb, which cleave the bound precursor miRNA to generate 3p and 5p strands, respectively, of the miRNA. One strand is loaded into the RNA-induced silencing...

William D. Foulkes, Anne-Laure Chong, Hannah D. Hosein et al. · 0 citations

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