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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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William Junior Khalil

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Review Open access Sep 2026

Mitochondria–Endoplasmic Reticulum Crosstalk in Pancreatic β-Cell Stress: A Driver of Diabetes

Pancreatic β-cell failure is central to the pathogenesis of type 2 diabetes (T2D), developing when chronic metabolic stress overwhelms the adaptive capacity of these cells. Because insulin biosynthesis and glucose-stimulated secretion depend on tightly coordinated organelle function, crosstalk between the endoplasmic r...

S. Niinuma, A. S. Takemoto, William Junior Khalil et al. · 0 citations

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