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William R. Brothers

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Open access Jul 2026

ESCAPE: assigning site-specific activity to covalent ligands in cells by prime editing

ESAPE (Endogenous Site-specific Competition Assays using Prime Editors using Prime Editors), a platform for the site-resolved functional analysis of covalent ligands in cells, identifies multiple covalent ligand-protein interactions that impair cancer cell growth.

Jason Tse, William R. Brothers, Rachel E. Hayward et al. · 0 citations

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