Author

Willow Coyote-Maestas

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Open access Sep 2026

Cardiomyocyte vulnerability to lamin polymer disruption revealed by saturation mutagenesis

Hundreds of mutations to the broadly expressed LMNA gene cause disease primarily within cardiac, muscular, and adipose tissues1. Tissue-specific pathogenesis arises when mutant protein dysfunction collides with the unique demands of a specific cell type. Here, we decipher the cell-type-specific consequences of ∼15,000...

Jessica Mella, Abigail E. Hein, Navraj Lally et al. · bioRxiv · 0 citations

Open access Aug 2026

Efficient experimental characterization of the GPCRome via deep receptor scanning

G protein-coupled receptors (GPCRs) mediate a variety of signaling pathways and represent the most common class of pharmaceutical target. While advances in structural biochemistry have provided deep functional insights into key receptors, many of the 800+ human GPCRs remain understudied. We introduce a versatile “deep...

A. Tedman, Muskan Goel, Sohan S. Shah et al. · Nature Communications · 0 citations