Open access
Aug 2026
Disease mutations in the PWWP domain of DNMT3A affect chromatin recruitment through multiple mechanisms
Understanding of the molecular mechanisms by which DNMT3A PWWP-domain mutations are mechanistically heterogeneous is advanced, providing a biochemical framework that contributes to distinct disease phenotypes.
Hannah Wapenaar, Gillian Clifford, Francesca Taglini et al.
· bioRxiv · 0 citations