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Woochul Chang

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Open access Jul 2026

A Cerebral Organoid Model of Familial Alzheimer’s Disease Using Amyloid Precursor Protein Mutation, Val669Leu (APPSeoul)

These results demonstrate the successful establishment of hESC-derived 2D and 3D AD models based on the APPSeoul fAD mutation, and investigate the effects of BACE1 inhibitor IV, a β-secretase inhibitor, in the CO model.

Wonyong Jung, Seung Tack Oh, M. Choe et al. · 0 citations

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