Open access
Oct 2026
Monkeypox virus M2 rewires nucleocytoplasmic transport to coordinate host translation suppression and immune evasion
Host shutoff is a conserved viral strategy to dismantle cellular defenses, yet the molecular orchestrators in large DNA viruses remain poorly defined. Through a systematic functional screen of the monkeypox virus (MPXV) proteome, we identify M2 as a potent, multifunctional effector that executes a global blockade of ho...
Xin Huang, Yi-Lin Yang, Wei Wang et al.
· bioRxiv · 0 citations