Wuyue Zhou

Mutant p53 gains RNA-binding activity to reprogram translation and mitochondrial function

SUMMARY Tumor suppressor p53 is a transcription factor mutated in ~50% of cancers. Somatic mutations in the DNA-binding domain abolish tumor suppression and thus lead to a loss-of-function activity, while a small subset of recurrent “hotspot” mutants have been shown to confer gain-of-function activities. Using an intei...