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Author

Wyatt C. Powell

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Open access Aug 2026

Cofactor-Free Tau Filaments Are Dynamic and Undergo Structural Evolution Driven by Thermodynamic Control

Environmental factors, such as mechanical stress and/or polyanions, play an important role in promoting the thermodynamic stability of otherwise dynamic tau fibrils, and it is speculated that, in patients, such factors might contribute to the maturation of disease-specific conformers.

Wyatt C. Powell, Nicholas L. Yan, Eric Tse et al. · 0 citations

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