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X. Lv

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Open access Oct 2026

Development of A10P3C, an isoform-selective inhibitor of EGLN2, for targeting breast cancer.

Oxygen sensing signaling is mainly mediated by EGLN prolyl hydroxylases, which plays important roles in physiology and diseases. Among them, EGLN2 plays an oncogenic role in breast cancer. However, the development of isoform-selective EGLN2 inhibitors remains a major challenge. Here, we report the identification of A10...

Qian Liang, Hui-Min Zhu, Ban-Chieh Huang et al. · 0 citations

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