Author

X. Qiu

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Open access Sep 2026

A tumor-cell MHC-II program is associated with checkpoint-blockade outcomes across stages of bladder cancer

Purpose A minority of patients with bladder cancer derive lasting benefit from immunotherapy, and current biomarkers capture only part of the biology. We evaluated whether tumor-cell MHC class II defines an immune state associated with outcome across disease stages and after PD-1/PD-L1 blockade. Experimental Design We...

J. Bellmunt, Ying-Tian Xie, M. Munoz et al. · bioRxiv · 0 citations

Open access Sep 2026

EZH2-dependent phenotypic plasticity reveals TTP-associated and mTORC1 therapeutic vulnerabilities in lethal prostate cancer.

Phenotypic plasticity is a recognized mechanism of therapeutic resistance in prostate cancer (PCa); however, current knowledge of its underlying drivers and therapeutic interventions remain limited. Using genetically engineered mouse models (GEMMs) devoid of Pten and Rb1, we previously demonstrated the chromatin reprog...

Beatriz German, K. Morel, Teia Noel et al. · Cell Reports Medicine · 0 citations

Open access Aug 2026

ACKR1-expressing venous endothelial cells establish a pro-fibrotic niche in pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by excessive extracellular matrix deposition and irreversible architectural distortion of the lung. Fibrotic remodeling is driven by dynamic interactions among endothelial, fibroblast, epithelial and immune cells. Although pulmonary endothe...

K. Kontodimas, A. Raslan, Benjamin Spira et al. · bioRxiv · 0 citations