Ovarian cancer is the deadliest gynecological malignancy due to poor drug targeting, severe toxicity, and an immunosuppressive tumor microenvironment (TME). To address this, a pH/GSH dual-responsive bacterial-nanoparticle system (VNP@BD-Poly) based on attenuated Salmonella VNP20009 (VNP) was developed. A bovine serum a...
Tissue repair is a highly coordinated process, yet dysregulated fibrosis often diverts healing toward scar formation, resulting in permanent structural and functional impairment. Achieving scarless regeneration requires precise modulation of the wound microenvironment to support functional tissue reconstruction. Hydrog...
Shuang-Li Zhu, Ying-Xun Shi, Hao-Ran Wang et al.· Bioactive Materials· 0 citations
Living bacterial therapy offers strong tumor‐targeting and deep penetration into hypoxic regions, but its therapeutic potential is hindered by biosafety risks from bacterial proliferation after treatment. Herein, we designed a trigger‐destructive bacterial system that combines precise tumor targeting with controlla...
In vivo studies in diabetic Sprague-Dawley rats model demonstrated that CC-pMnO2-Vet@PNAA established a coordinated immune-mechanical microenvironment, achieving rapid and scar-free wound healing.
