X. Zeng

Association between plasma brain-derived p-tau variants and anxiety phenotypes in older adults

Clinical utility of plasma APOE proteotyping for Alzheimer's disease risk and prognosis

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder strongly influenced by genetic factors, with apolipoprotein E (APOE) {epsilon}4 allele being the most established risk variant. Although DNA-based genotyping remains standard, plasma proteotyping may provide scalable, isoform-specific alternat...

Analytical performance of a delayed-centrifugation blood collection tube for remote blood biomarker assessment

Current biobanking guidelines require in-person blood collection and immediate processing for Alzheimer's disease (AD) biomarker assessment. We recently reported that the P100 blood collection tubes containing protease inhibitors improve protein biomarker stability over delayed centrifugation periods. However, whether...

Brain region- and solubility-dependent proteomic signatures of neurofibrillary tangle pathology in Alzheimer's disease

Neurofibrillary tangles (NFTs) are a hallmark of Alzheimer's disease. However, the molecular basis underlying their spatial heterogeneity and biochemical complexity remain unclear. To address this, we performed mass spectrometry-based proteomic profiling of two neocortical regions with different susceptibilities to NFT...